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2019 CNS Meriana ea Meriana ea Meriana ea Motsoako oa Meriana (GM1) Kolobe ea Brain (37758-47-7)

2019 CNS Meriana ea Meriana ea Meriana ea Motsoako oa Meriana (GM1) Kolobe ea Brain (37758-47-7)

Tlhaloso ea Meta

Fumana karolo ea GM1 meleng ea methapo ea kutlo, thepa ea eona e khahlanong le botsofali, le liphello tsa kliniki mekhoeng ea methapo ea methapo le ea pherekano.

Monosialotrahexosylganglioside Solidum (GM1) ke eng?

Sodium ea Monosialotetrahexosylganglioside ke motsoako oa li-neurotrophics eo kakaretso e leng eona GM1.

Li-gangliosides ke tsa sehlopha sa lihlopha tsa ganglio, tse nang le glycosphingolipid e nang le libaka tsa sialic acid tse ling ka mokokotlo oa tsoekere. Sehlopha sa sialated polysaccharide se kopanya le ceramide ka ho kopanya β-glycosidic. Ha li etsoe kahare feela ka lesela la plasmic la neuronal empa hape le li-reticulum tsa endoplasm.

Le hoja li etsa karolo ea 0.1% ea boima ba boko bo feletseng, li-gangliosides li na le hoo e batlang e le 10% ea lipids kaofela. Li etsa hore ho be le likarolo tse sa tšoaneng tsa seleng, apoptosis, neuroprotection, le ho lokolloa ha li-neurotrophin.

Monosialotetrahexosylganglioside ke motsoako o sa tšoaneng o nang le ketane ea oligosaccharide le ceramide. Molek'hule e na le li-hydrophilic le lipophilic. Ho itšehla thajana metsing le mafura, Monosialotetrahexosylganglioside e ka ba bonolo ho tsamaea ka tsela e thibelang mali le boko.

Sodium ea Monosialotetrahexosylganglioside GM1 e na le karolo ea bohlokoa ea 'mele bokong. E na le lisebelisuoa tse kang ho lokisa likokoana-hloko tsa meriana, ho hlaphoheloa ha mosebetsi, le ho tsosolosoa ha li-neurone ka mor'a kotsi. Ka lebaka lena, sodium ea Monosialotetrahexosylganglioside e thusa ho phekola kotsi e ka hare ea methapo. Tse ling tsa maloetse a amanang le ona li akarelletsa ho sithabela ha pelo, ho senyeha ha methapo ea pelo le ho lematsa ha lisele tsa mokokotlo. E mengata e lebisitsoe moo ho nang le ts'oaetso ea lisele tsa methapo.

Histori ea Sodium ea Monosialotetrahexosylganglioside (GM1)

Thuto ea GM1 le karolo ea eona ho eona neuroprotection e khutlela ho 1970s. Ho tloha ka nako eo, lipatlisiso tsa bo-rasaense li bontšitse hore li thahasella motsoako ka ho etsa litloaelo tsa lisele le lithuto tsa liphoofolo. Liteko tsohle li ne li lebisitse tlhokomelo ea bohlokoa ba GM1 ha ho e-ba le maloetse a mangata.

Ho 1986, ka TRB SA, sodium ea Monosialotetrahexosylganglioside e ile ea qala ka molao tlas'a lebitso la khoebo, GM-1. Kaha liphello tsa lithuto tsa liphoofolo li ne li tšepisa, lingaka tsa United States li ile tsa qala ho etsa lipatlisiso ka liphello tsa Monosialotetrahexosylganglioside sodium (GM1) ho batho. Lihlooho tsa thuto ena e ne e le bakuli ba nang le tšenyo ea CNS ka lebaka la ho lematsoa ha mokokotlo, leqeba, lefu la Parkinson le Alzheimer.

Ho tloha ka nako eo, ho bolela hore Argentina le Italy li amohetse kopo ea eona ea phekolo e le moriana oa ngaka bakeng sa ho phekoloa ha meriana.

Sodium ea Monosialotetrahexosylganglioside(GM1)Mekhoa ea Motheo

Sodium ea Monosialotetrahexosylganglioside (GM1) boko ba kolobe (37758-47-7)

Sodium ea Monosialotetrahexosylganglioside(GM1) songolo

CAS No. 37758-47-7
Name Product Sodium ea Monosialotetrahexosylganglioside (GM1) Kolobe ea Brajo
Lebitso la IUPAC (2S,4S,5R,6R)-5-acetamido-2-[(2S,3R,4R,5S,6R)-5-[(2S,3R,4R,5R,6R)-3-acetamido-5-hydroxy-6-(hydroxymethyl)-4-[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-2-[(2R,3S,4R,5R,6R)-4,5-dihydroxy-6-[(E,2R,3S)-3-hydroxy-2-(icosanoylamino)icos-4-enoxyl]-2-(hydroxymethyl)oxan-3-yl]oxy-3-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-4-hydroxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylic acid
Sehlopha sa Lithethefatsi Sphingolipids
Melting Point 207 - 230 ° C
Molecular Formula C77H139N3O31
'Mele oa limolek'hule 1546.841 gmol-1
Solubility · Metsi
· Ho ruruha haholo ka methanol / chloroform
· Ho hang e sa tšolohe ka har'a ethanol ea anhydrous
Ponahalo Ho soeufetse ho fihlela ho soeufalitsoe ka phofo e tšoeu
Ho hloeka 98%
Storage Mocheso -20 ° C
Shelf Life Lilemo tse peli
pH 5.0 ho 6.5
Li-synonyms · Monosialoganglioside GM1
·Ganglioside GM1

Sodium ea Monosialotetrahexosylganglioside(GM1) Mokhoa oa Khato

Monosialotetrahexosyl ganglioside e sebetsa ka litsela tse ngata. Molek'hule ke sehlahisoa sa mesebetsi e mengata ea phekolo ea tsamaiso ea methapo.

Ka lehare la sele ea boko, mesebetsi ea Monosialotetrahexosylganglioside ho boloka boima ba ione ka hare le ka ntle ho lisele tse nyenyane. Hase feela ho ntlafatsa ho se hlokehe, empa e boetse e hlahisa pompe ea ioni ea sodium le ea calcium.

Haeba ho e-na le kotsi ea meriana, Sodium ea Monosialotetrahexosylganglioside (GM1) e kena ho sireletsa sebopeho sa makhasi. E fokotsa tšebetso ea phospholipase A2, e lekanyetsa motlakase oa khalsiamo, 'me e fokotsa ho thehoa ha li-radicals tsa mahala.

Matšoao a bongobo a matlafatsa mosebetsi oa protein kinase liseleng, e ka 'nang ea e-ba le boikarabello ba ho apoptose. GM1 e thibela le ho fetola mokhoa ona ka ho tšoara metabolism ea liprotheine ka har'a cytoplasm le nucleus.

Ka mitochondrion, Monosialotetrahexosylganglioside e sebetsa ho hlahisa tlhahiso ea ATP le mosebetsi oa eona oa synthase. E lokisa litšenyehelo tse ka khonehang kethung ea lipalangoang tsa elektronike le ho ntlafatsa phosphorylation ea li-oxidative. Ka lebaka leo, boko ba mitochondrial bo sebetsang bo ntse bo phetse hantle.

Meriana ea monosialotetrahexosylganglioside sodium e etsa hore limela li be le limela ka ho lebisa tlhokomelo ea lintho tse hōlang liphatlalatsong tse khethehileng. Ketsahalo ena e boetse e etsa hore methapo ea methapo e sebetse 'me e khothalletsa batho hore ba hlaphoheloe ke mafu. Tabeng ea ho senyeha ha bobeli, mohlomong ka lebaka la tšenyo ea dopamine neuron, Monosialotetrahexosylganglioside e tla tsitsisa phello le ho ntlafatsa ho phela ha li-neurons tsena.

2019 CNS Meriana ea Meriana ea Meriana ea Motsoako oa Meriana (GM1) Kolobe ea Brain (37758-47-7)

Monosialotrahexosylganglioside Solidum (GM1) Liphello

Le hoja li-gangliosides li le bobebe bokong, mesebetsi ea tsona e khōlō haholo. Limolek'hule tsena li na le tšusumetso e ntle ho kgolo, ho tsosolosa, ho lokisa le ho sireletsa maqhubu a methapo.

GM1 e fokotseha ka lilemo. Botsofali bo amahanngoa le tšebeliso e feteletseng ea boko, ho ba le botenya ba mocheso, likotsi tsa kotsi tsa meriana, kapa ho senyeha ha mohopolo. Ntle ho moo, maloetse a maholo a khale a kang cerebral palsy, stroke le dementia a ka 'na a phalla.

Ho tlatswa ha nako e telele ea GM1 ho thusa ho laola boholo ba metsoako ea botsofali. Tse ling tsa liphello tse ntle tsa Monosialotetrahexosylganglioside sodium (GM1) li kenyelletsa ho phekoloa ha lefu la Alzheimer, lefu la sethoathoa, lefu la sethoathoa le lefu la pherekano. Ntle ho moo, tlatsetso e fokotsa botsofali ka ntlafatsa mohopolo.

Tšebeliso ea GM1 liketsong tsa kliniki e hole haholo. Ka mohlala, linaha tse 'maloa tsa Europe le Amerika li' nile tsa nka ente ea sodium ea monosialotetrahexosylganglioside ho laola mafu a CNS.

Tlatsetso e eketsa kholo ea lisele tse nang le methapo ea kutlo, nts'etsopele ea lik'hemik'hale tsa boko le thibelo ea mafu a kelello. Therapeutically, molek'hule ena e hlollang e tšoara maloetse a boko, ho tsoa lik'hemik'hale, ho bolaoa ha masapo, le ho tsoa likotsi tsa lisele tsa khatello ea kelello.

Tlhahlobo ea bohlokoa ka ho fetisisa thutong le tšebelisong ea motsoako ona ho batho e ne e fumane hore ha ho na liphello tse kotsi tsa Monosialotetrahexosyl ganglioside sodium (GM1).

Liphello tsa GM1 hase feela likhopolo-taba. Ka 1976, Ceccarelli e thehile hore li-gangliosides tse ngata li tsosolosa methapo e meholo le ea phekolo ea meriana le ho lokisoa ha lisele tse senyehileng. Ho sibolloa hona ho ile ha beha motheo o tiileng oa litsebi tse ileng tsa bontša thahasello ho ithuta karolo ea GM1 tsamaisong ea methapo e meholo.

Liteko tse ngata tsa bongaka li tiisa hore Monosialotetrahexosylganglioside e na le phello e ntle ho kgolo, ho khetholla, ho nts'etsopele le ho tsosolosoa ha lisele tsa methapo ea pelo. Ho feta moo, lipatlisiso li khutlisetsa matla a GM1 ka ho thibela mali, lefu la neuroplasticity le synaptic transmission.

Tabeng ea mahlaba-a-laotsoe, ho noa monosiana o moholo oa Monosialotetrahexosylganglioside sodium e tla ama tsamaiso ea methapo ka litsela tse ngata. Molek'hule e ke ke ea susumetsa feela moloko oa dendritic oa lisele tsa methapo empa hape e eketsa lebelo la tsona la ho pholoha. Ntlha ea bobeli, tlatsetso e na le karolo ea bohlokoa ho lokisa, ho tsosolosoa le ho ts'oaroa.

Monosialotrahexosyl Ganglioside Solidum (GM1) Mokhoa oa Tlhahiso

Ho tla fihlela joale, monosialotetrahexosyl ganglioside ke eona feela phekolo ea CNS e hlahang ka tlhaho.

Molek'hule ke karolo ea ganglioside, e hlahisoang ka ho qetela membrane ea neural cell of mammals. Ka lebaka la litlhoko tsa eona tse nang le maruo, litsebi tsa bo-rasaense le lingaka li khonne ho li tlosa le ho li sebelisa ha ho etsoa likokoana-hloko tsa monosialotetrahexose tsa meriana.

Re ntša monosialotetrahexosyl ganglioside ho tloha lisele tsa mammalian. Le hoja u ka arola molek'hule ho tsoa ho khomo kapa pōli, mokhoa o bolokehileng ka ho fetisisa ke ho ntša boko ba kolobe. Lebaka ke hore ho tlosoa ha monosialotetrahexosyl ganglioside ho tloha ho likhomo kapa lipōli ho ka etsahala hore ho fetisoe li-prions tse tšoaetsanoang joalo ka lefu la likhomo le lefu la sethoathoa.

Lisebelisoa tse hlahang bakeng sa lekhetho la lab la Monosialotetrahexosylganglioside (GM1) li fumaneha, li sebetsa hantle ebile li na le moruo. Re u fa GM1 e sireletsehileng le e hloekileng ho tsoa likolobeng tsa kolobe, kaha mokhoa oo ha o fetise tšoaetso ho batho.

Bakeng sa lihlahisoa tse ngata, re sebelisa mokhoa oa chloroform-methanol-extraction method. Ka mor'a moo, re etsa phapanyetsano ea anion le karohano ea boholo-holo ea ho khetholla chromatographic. Tlhoekiso ena e hlahisa molek'hule e tloaelehileng, e leng> 98% e hloekileng ka HPLC.

fihlela qeto e

Liphello tsa Monosialotetrahexosyl li-ganglioside li bohlokoa liketsong tsa kliniki. Ke moriana o amohelehang oa ngaka bakeng sa ho sebetsana le mathata a kelello le kalafo ea kotsi e ka sehloohong ea methapo.

Ho sa tsotellehe hore na u batla ho reka GM1 bakeng sa phekolo ea meriana kapa lipatlisiso, re u tiisetsa hore u na le sehlahisoa se phahameng. Re hlahisa li-volume Monosialotetrahexosylganglioside sodium (GM1) phofo tlas'a maemo a amohelehang a boleng ba boleng.

References

  1. Schneider, JS, Roeltgen, DP, le al. (1998). Maloetse a Parkinson: Mosebetsi o ntlafalitsoeng Ka Phekolo ea GangXside ka GM1 Thutong e Laoloang ka Sebaka sa Bohlokoa.
  2. Bansal, AS, Abdul-Karim, B., Malik, RA, le al. (1994). Li-IgM Ganglioside GM1 Likokoana-hloko ho bakuli ba nang le lefu la ho itšireletsa habonolo kapa la lefu la kelello, le Laola. Journal Journal Clinic Pathology.
  3. Mocchetti, I. (2005). Gangliosides e sa tloaelehang, Pulasetiki ea Neuronal le Repair, le Neurotrophins.
  4. Aureli, M., Mauri, L., Ciampa, MG, Prinetti, A., Toffano, G., le al. (2016). GM1 Ganglioside: Liphuputso tsa Nakong e Fetileng le Bokamoso bo Tlang. Molecular Neurobiology.
  5. Bian, L., Yang, J., le Sun, Y. (2015). Ho Isolation le Ho Hloekisoa ha Monosialotetrahexosylgangliosides ho tloha Pig Brain ka ho Khatholla le Liquidate Chromatography.